F57A8.4

Symbol: F57A8.4
Name: Protein F57A8.4
Entrez gene ID: 186430
Ensembl gene ID: F57A8.4
Species: Worm (Taxid: 6239)

Functional description:
Protein F57A8.4; Protein F57A8.4 [Source:UniProtKB/TrEMBL;Acc:Q20915] [Ensembl]

Observation:

F57A8.4 encodes a rhodopsin-like G-protein coupled receptor that is known to sense light [11493519] and is downregulated in space. Mutation or RNA interference of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4 RNAi extends the mean, 75%ile and maximum lifespan by 34, 39, and 61%. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380].

Mutation and RNAi of F57A8.4 suppresses pheromone-induced dauer formation [22768380].



Interventions:
  • F57A8.4 RNAi +34% +61%
  • F57A8.4 mutation +18 to +38% +42 to +68%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • R11F4.2 (6239)
  • T11F9.1 (6239)
  • ZK1307.7 (6239)
  • F32D8.10 (6239)
  • Y41D4B.24 (6239)
  • F56A11.4 (6239)
  • Y40C5A.4 (6239)
  • Y37E11AL.1 (6239)
  • C47E8.3 (6239)
  • F57A8.4 (6239)
  • E04D5.2 (6239)
  • C54D10.5 (6239)



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