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Symbol: CG4389 Name: CG4389 gene product from transcript CG4389-RA Entrez gene ID: 34276 Ensembl gene ID: FBgn0028479 Species: Fly (Taxid: 7227) Functional description: electron transport flavoprotein Beta subunit; CG4389 gene product from transcript CG4389-RA; The gene Mitochondrial trifunctional protein α subunit is referred to in FlyBase by the symbol Dmel\Mtpα (CG4389, FBgn0028479). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: long-chain-3-hydroxyacyl-CoA dehydrogenase activity; long-chain-enoyl-CoA hydratase activity. There is experimental evidence that it is involved in the biological process: response to starvation; determination of adult lifespan; fatty acid beta-oxidation; wound healing. 5 alleles are reported. The phenotypes of these alleles are annotated with: adult fat body; lipid particle. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: 3-hydroxyacyl-CoA dehydrogenase, C-terminal; 3-hydroxyacyl-CoA dehydrogenase, NAD binding; 6-phosphogluconate dehydrogenase, C-terminal-like; Crotonase, core; Dehydrogenase, multihelical; Enoyl-CoA hydratase/isomerase, conserved site; Fatty acid oxidation complex, alpha subunit, mitochondrial; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages. [FlyBase] Observation: Muscle specific RNAi knockdown of CG489 which reduces its mRNA levels by 25-35%, significantly reduces the DR-dependent lifespan extension. CG4389 RNAi animals exhibit only 20% increase while controls display an lifespan increase by 123% upon DR [22768842]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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