Denigma

asg-2

Symbol: asg-2
Name: ATP synthase subunit 2
Entrez gene ID: 180956
Ensembl gene ID: C53B7.4
Species: Worm (Taxid: 6239)

Functional description:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. [UniProt]

Observation:

Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594].



Interventions:
  • asg-2 mutation

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • asg-1 (6239)
  • asg-2 (6239)

    • Note: Is the reference for the lifspan effect of asg-2 correct? It seems that its that it is not mentioned there at all.

    Edit \ Update (Admin) | Delete

    Comment on This Data Unit