TPS2

Symbol: TPS2
Name: Trehalose-6-phosphate PhoSphatase 2
Entrez gene ID: 851646
Ensembl gene ID: YDR074W
Species: Yeast (Taxid: 4932)

Functional description:
Tps2p; Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000002481] [Ensembl]

Observation:

Deletion of TPS2 has no effect on replicative lifespan and does not prevent lifespan extension by high osmolarity [12391171].

TPS2 is required for trehalose biosynthesis in response to osmotic stress [8444170].



Interventions:
  • TPS2 deletion -61%

  • Assays: Replicative Lifespan

    Classification:
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • tpp1 (4896)
  • TPS2 (4932)
  • KLLA0E10143g (28985)
  • AGOS_AGR132W (33169)
  • GeneID:2676473 (148305)
  • NCU05041 (5141)
  • ATTPS7 (3702)
  • Os01g0730300 (4530)
  • Os01g0749400 (4530)
  • Os05g0517200 (4530)



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