SUN4

Symbol: SUN4
Entrez gene ID: 855659
Ensembl gene ID: YNL066W
Species: Yeast (Taxid: 4932)

Functional description:
Sun4p; Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family [Source:SGD;Acc:S000005010] [Ensembl]

Observation:

Disruption of SUN4 shortens mean (87.5% of normal), but not maximum, replicative lifespan in BKY1-14c [Austriaco, N.R. (1996) “UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae.” Ph.D. Thesis, Massachusetts Institute of Technology; 8810036]

SUN4 mutation causes failure of daughter cells to completely detach and results in a multi-budded morphology [10683261].



Interventions:
  • SUN4 deletion -12.5%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • psu1 (4896)
  • SIM1 (4932)
  • SUN4 (4932)
  • KLLA0F04433g (28985)
  • AGOS_AER372C (33169)



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