JUG

Symbol: JUG
Name: Jugelone treatment


Observation:

High jugelone concentrations led to premature death. Low juglone concentrations are tolerated well and cause a prolongation of lifespan that is associated with increased expression of small heat-shock protein HSP-16.2, enhanced glutathione levels, and nuclear translocation of DAF-16. Silencing or deletion of daf-16 prevents jugelone-induced adaptations. RNA-interference for SIR-2.1 has the same effects as daf-16 deletion but does not affect nuclear accumulation of DAF-16. DAF-16- and SIR-2.1-dependent alterations in gene expression after challenge with reactive oxygene species lead to lifespan extension [19597959].



Interventions:
  • Jugelone treatment

  • Assays: Organismal Lifespan

    Classification:
  • Gero-Enhancer
  • Gero-Suppressant




  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit