|
Symbol: SIRT3 Name: sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) Alias: SIR2L3 Entrez gene ID: 64384 Ensembl gene ID: ENSMUSG00000025486 Species: Human (Taxid: 9606) Functional description: however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]; NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues (By similarity). Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. [UniProt] Observation: The TT genotype of a silent G/T transition (G477T) in the SIRT3 gene was found to be correlated with longevity in males (but not females) in a study of individuals from Calabria, Italy [14580859]. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit