DNM1

Symbol: DNM1
Name: Dnm1p
Entrez gene ID: 850686
Ensembl gene ID: YLL001W
Species: Yeast (Taxid: 4932)

Functional description:
Dnm1p; Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance [Source:SGD;Acc:S000003924] [Ensembl]

Observation:

Deletion of DNM1 extends significantly mean and maximum lifespan by 49 and 111% in FY10 strain and by 15 and 12% in BY4741 strain [17173038].



Interventions:
  • DNM1 deletion +15 to +49% +12 to +111%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • DNM1L (9606)
  • DNM1L (9598)
  • DNM1L (9615)
  • DNM1L (9913)
  • Dnm1l (10090)
  • Dnm1l (10116)
  • DNM1L (9031)
  • dnm1l (7955)
  • Drp1 (7227)
  • AgaP_AGAP008896 (7165)
  • drp-1 (6239)
  • dnm1 (4896)
  • DNM1 (4932)
  • KLLA0F12892g (28985)
  • AGOS_AAL174C (33169)
  • GeneID:2684516 (148305)
  • NCU09808 (5141)
  • Os04g0381000 (4530)



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