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Symbol: Rgn Name: regucalcin Entrez gene ID: 19733 Ensembl gene ID: ENSMUSG00000023070 Species: Mouse (Taxid: 10090) Functional description: Senescence marker protein-30 (SMP30) is a calcium-binding protein that decreases in an androgen-independent manner with aging and protects cells from apoptosis [12368201]. SMP30 is expressed primarily in the liver where it suppresses cell proliferation [11472560] and regulates calcium homeostasis by enhancing plasma membrane calcium ion- pumping activity [10360682].; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). [UniProt] Observation: Survival among make animals lacking Rgn (alias SMP30) is 50% at 180 days compared to 100% among controls [N. Maruyama, unpublished data]. SMP30-/- mutant mice are indstuguishibale form their SMP30+/+ littermates in terms of development and fertilization capacity [12368201]. However, -/- mice were more susceptible to liver injury after treatment with anti-FAS antibody. SMP30-/- hepatocytes cultures in vitro are more susceptible to apoptosis induced by tumor-necrosis factor (TNF-alpha) plus actinomycin D (ActD) than SMP30+/+ hepatocytes. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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