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Symbol: rad-8 Name: RADiation sensitivity abnormal/yeast RAD-related 8 Entrez gene ID: 3565366 Ensembl gene ID: F56H1.6 Species: Worm (Taxid: 6239) Functional description: Protein RAD-8; rad-8 encodes a protein with similarity to dehydrogenases/reductases that is orthologous to the human mitochondrial protein RTN4IP1 (reticulon 4 interacting protein 1); rad-8 was identified in screens for loci that when mutated result in abnormal radiation sensitivity; rad-8 mutant animals are hypersensitive to ultraviolet irradiation, methyl viologen (paraquat) treatment, and high concentrations of oxygen (50% or greater); young adult rad-8 hermaphrodites produce many inviable embryos, but fertility increases as the animals age; rad-8 mutant animals are also long-lived at 16 degrees C, but not at 20 degrees C; a RAD-8::GFP fusion protein is widely expressed and seen in the neurons, pharynx, muscles, and intestine; a RAD-8::GFP fusion protein localizes to mitochondrion; increased oxygen sensitivity displayed by rad-8 mutants can be rescued by overexpression of human RTN4IP1. [WormBase] Observation: Mutation of rad-8 increases lifespan by approximately 30% at 16 degree Celsius but not at 20 degree Celsius [8169328; rad-8 mutants are hypersensitive to UV radiation, but not X-rays or MMS [7152245] Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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