Denigma: Factor

PUF4

Symbol: PUF4
Name: PUmilio-homology domain Family 4
Entrez gene ID: 852870
Ensembl gene ID: YGL014W
Species: Yeast (Taxid: 4932)

Functional description:
Puf4p; Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors [Source:SGD;Acc:S000002982] [Ensembl]

Observation:

Deletion of PUF4 has no effect on replicative lifespan in either uth4-14c (C-terminal truncation) or UTH4 background. However, PUF4 is required for lifespan extension by the semi-dominant Sir4-42 allele in the uth4-14c background [9150138].

PUF4 is required for nucleolar relocalization of Sir3 in a Sir4-42 background [9150138]. puf4;mpt5 double deletion strain has increased telomere silencing relative to the mpt5 single mutant [9651685].

Interventions:

PUF4 deletion

Assays: Replicative Lifespan

Classification:

No Age Effect

References:

9150138: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

Aging Relevance Analysis/Source:

GenAge