Denigma

POL1

Symbol: POL1
Name: POLymerase 1
Entrez gene ID: 855621
Ensembl gene ID: YNL102W
Species: Yeast (Taxid: 4932)

Functional description:
Pol1p; Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis [Source:SGD;Acc:S000005046] [Ensembl]

Observation:

Mutation of POL1 results in a 20-60% reduction in mean lifespan (in SS111) [12024027]



Interventions:
  • POL1 deletion -20 to -60%

    • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • POLA1 (9606)
  • POLA1 (9615)
  • POLA1 (9913)
  • Pola1 (10090)
  • POLA1 (9031)
  • pola1 (7955)
  • DNApol-alpha180 (7227)
  • AgaP_AGAP001929 (7165)
  • Y47D3A.29 (6239)
  • pol1 (4896)
  • POL1 (4932)
  • KLLA0C13255g (28985)
  • AGOS_AER381C (33169)
  • GeneID:2684552 (148305)
  • NCU07870 (5141)
  • ICU2 (3702)
  • Os01g0868300 (4530)



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