Denigma

dnc

Symbol: dnc
Name: dunce
Entrez gene ID: 31309
Ensembl gene ID: FBgn0000479
Species: Fly (Taxid: 7227)

Functional description:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory (By similarity). [UniProt]

Observation:

cAMP phosphodiesterase-deficient dunce mutants have an extended maximum lifespan by about 70% [17369827].



Interventions:
  • dnc mutation +70%

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PDE4D (9606)
  • PDE4D (9598)
  • PDE4D (9615)
  • PDE4D (9913)
  • Pde4d (10090)
  • Pde4d (10116)
  • LOC566998 (7955)
  • dnc (7227)
  • AgaP_AGAP000236 (7165)
  • pde-4 (6239)

    • Inparanoids
  • FBpp0070485 (7227)
  • ENSMUSP00000112991 (10090)
  • ENSRNOP00000007738 (10116)
  • ENSMMUP00000009841 (9544)
  • ENSP00000384806 (9606)



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