Denigma: Factor

NR3C1

Symbol: NR3C1
Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Alias: GRL
Entrez gene ID: 2908
Ensembl gene ID: ENSG00000113580
Species: Human (Taxid: 9606)

Functional description:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). [UniProt]

Observation:

The ER22/23EK variant of NR3C1 is correlated with longevity as well as relative gluccoritcoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels in males [15276593].NR3C1 was found to be associated with longevity [22279548].

Assays: Organismal Lifespan

Longevity Associated Variants:

rs2963154 0.0010712 [22279548]

Classification:

Longevity-Associated

References:

15276593: Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

Aging Relevance Analysis/Source:

GenAge