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Symbol: Npy Name: neuropeptide Y Entrez gene ID: 24604 Ensembl gene ID: ENSRNOG00000009768 Species: Rat (Taxid: 10116) Functional description: Neuropeptide that reduces blood pressure and anxiety; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. [UniProt] Observation: Overexpression of Npy under the control of its own promoter results in increased mean and maximum lifespan. However the observed lifespan extension is relatively small (p = 0.0059 by Wilcoxin test and p = 0.05 by t-test; n = 20) [12668588]. The blood pressure of Npy transgenic rats was significantly lower as compared with nontransgenic siblings. Food intake and weight were not significantly different compared to controls [12668588]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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