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Symbol: NNT1 Name: Nicotinamide N-methylTransferase 1 Entrez gene ID: 850991 Ensembl gene ID: YLR285W Species: Yeast (Taxid: 4932) Functional description: Nnt1p; S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination [Source:SGD;Acc:S000004275] [Ensembl] Observation: Deletion of NNT1 decreases mean and maximum lifespan by 9 and 19%. 0.5% glucose DR extends the mean and maximum lifespan of NNT1 deletion mutants by 35 and 40%. Overexpression of NNT1 by 5-fold extends mean and maximum replicative lifespan by 18 and 23%, which is approximately of the same magnitude as the lifespan extension obtained from DR. DR in NNT1 overexpression mutant fails to significantly affect the lifespan and only results in extended mean lifespan by 12% and reduced maximum lifespan by 11%. NNT1 overexpression increases rDNA silincing, whereas deletion decreases rDNA silencing. Overexpression of human nicotinamide N-methyltransferase also increases rDNA silencing [12736687]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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