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Symbol: NCA3 Name: Nuclear Control of ATPase 3 Entrez gene ID: 853326 Ensembl gene ID: YJL116C Species: Yeast (Taxid: 4932) Functional description: mitochondrial mRNA processing/modification [7586026; 1531141]; Nca3p; Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000003652] [Ensembl] Observation: Disruption in NCA3 shortens mean (87% of normal), nut not maximum replicative lifespan without causing any other gross changes in cell cycle parameters of growth characteristics [8810036]. In combination with an NCA2 disruption, NCA3 disruption causes a cryosensitive phenotype on non-fermentable carbon sources due to a defect in the F1-F0 ATP synthetase due to misbalancing of alternate spliceforms of mitochondrial mRNA encoding subunits 6 and 8 of the synthase [7586026]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: See and cite also: Austriaco, N. R., Jr. (1996). UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae. In Biology (Cambridge: Massachusetts Institute of Technology). Edit \ Update (Admin) | Delete |
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