Denigma

HSC80

Symbol: HSC80
Entrez gene ID: 855224
Ensembl gene ID: YMR186W
Species: Yeast (Taxid: 4932)

Functional description:
Heat shock protein; Hsc82p; Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock [Source:SGD;Acc:S000004798] [Ensembl]

Observation:

Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336].



Interventions:
  • HSC82 deletion

    • Assays: Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HSP90AB1 (9606)
  • LOC737497 (9598)
  • HSP90AB1 (9913)
  • Hsp90ab1 (10090)
  • Hsp90ab1 (10116)
  • HSP90AB1 (9031)
  • hsp90ab1 (7955)
  • Hsp83 (7227)
  • AgaP_AGAP006958 (7165)
  • daf-21 (6239)
  • hsp90 (4896)
  • HSP82 (4932)
  • HSC82 (4932)
  • KLLA0D12958g (28985)
  • AGOS_AFL148C (33169)
  • GeneID:2684932 (148305)
  • NCU04142 (5141)
  • HSP81-2 (3702)
  • AT5G56000 (3702)
  • HSP81-3 (3702)
  • Os09g0482400 (4530)
  • Os08g0500700 (4530)
  • Os09g0482100 (4530)
  • PF07_0029 (5833)



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