HAP5

Symbol: HAP5
Name: Heme Activator Protein 5
Entrez gene ID: 854540
Ensembl gene ID: YOR358W
Species: Yeast (Taxid: 4932)

Functional description:
Hap5p; Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex [Source:SGD;Acc:S000005885] [Ensembl]

Observation:

Deletion of HAP5 shortens replicative lifespan by approximately 40%. This is not a premature aging phenotype as "old" HAP5 cells do not become premature sterile or exhibit other biomarkers of yeast aging [9271578]. HAP5 null mutants are unable to grow on a non-fermentable carbon source [7828851].



Interventions:
  • HAP5 deletion -40%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • php5 (4896)
  • HAP5 (4932)
  • KLLA0A03696g (28985)
  • AGOS_ADR391W (33169)
  • GeneID:2675038 (148305)
  • NCU00116 (5141)



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