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Symbol: Gh1 Name: growth hormone 1 Entrez gene ID: 24391 Ensembl gene ID: ENSRNOG00000011207 Species: Rat (Taxid: 10116) Functional description: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. [UniProt] Observation: Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. However, animals carrying two copies of the transgene (tg/tg) have a slighlty shorter lifespan compared to -/- animals, indicating that an optimal dosage of Gh1 is nessary to achieve lifespan exentension and too little GH has a detrimental effect on longevity. tg/tg and tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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