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Symbol: Hk Name: Hyperkinetic Entrez gene ID: 31955 Ensembl gene ID: FBgn0001203 Species: Fly (Taxid: 7227) Functional description: Hyperkinetic; Hyperkinetic [Source:FlyBase gene name;Acc:FBgn0263220] [Ensembl]; The gene Hyperkinetic is referred to in FlyBase by the symbol Dmel\Hk (CG43388, FBgn0263220). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: voltage-gated potassium channel activity. There is experimental evidence that it is involved in the biological process: flight behavior; circadian sleep/wake cycle, sleep. 18 alleles are reported. The phenotype of these alleles is annotated with: leg. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Aldo/keto reductase; NADP-dependent oxidoreductase domain; Potassium channel, voltage-dependent, beta subunit, KCNAB; Potassium channel, voltage-dependent, beta subunit, KCNAB-related. Gene sequence location is X:10132277..10157518. [FlyBase] Observation: Genetic mutation in Hyperkinetic shortens lifespan through acceleration of the aging process. At 25 degree Celsius mean and maximum lifespan is reduced by 29 and 32%, while by 18 degree Celsius the reduction is 59 and 39% [8582611]. Interventions: Assays: Organismal Lifespan Mean: -29 to -59 Maximum: -32 to -39 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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