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Symbol: DNL4 Name: DNA Ligase 4 Entrez gene ID: 854166 Ensembl gene ID: YOR005C Species: Yeast (Taxid: 4932) Functional description: Dnl4p; DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth [Source:SGD;Acc:S000005531] [Ensembl] Observation: DNL4 deletion does not affect lifespan [10521401], although it renders cells defective for non-homologous end-joining [9242411] Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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