DJ-1alpha

Symbol: DJ-1alpha
Name: DJ-1α
Entrez gene ID: 36543
Ensembl gene ID: FBgn0033885
Species: Fly (Taxid: 7227)

Functional description:
CG6646 gene product from transcript CG6646-RA; DJ-1alpha [Source:FlyBase gene name;Acc:FBgn0033885] [Ensembl]; The gene DJ-1α is referred to in FlyBase by the symbol Dmel\DJ-1α (CG6646, FBgn0033885). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: response to oxidative stress. 11 alleles are reported. The phenotypes of these alleles are annotated with: eye; dopaminergic neuron; eye photoreceptor cell; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: DJ-1; ThiJ/PfpI. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. [FlyBase]

Observation:

RNA interference of DJ-1alpha shortens maximum lifespan by 13% and results in increased sensitivity to oxidative stress and motor impairments [17651920].



Assays: Organismal Lifespan
Maximum: -13

Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17651920: Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PARK7 (9606)
  • PARK7 (9598)
  • PARK7 (9615)
  • PARK7 (9913)
  • Park7 (10090)
  • Park7 (10116)
  • PARK7 (9031)
  • park7 (7955)
  • dj-1beta (7227)
  • DJ-1alpha (7227)
  • AgaP_AGAP000705 (7165)
  • djr-1.1 (6239)
  • djr-1.2 (6239)
  • SPAC22E12.03c (4896)
  • Os01g0217800 (4530)
  • PFF1335c (5833)

  • Inparanoids
  • ENSMUSP00000101300 (10090)
  • ENSRNOP00000052374 (10116)
  • ENSMMUP00000025846 (9544)
  • ENSP00000366713 (9606)



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