Symbol: DJ-1alpha Name: DJ-1α Entrez gene ID: 36543 Ensembl gene ID: FBgn0033885 Species: Fly (Taxid: 7227) Functional description: CG6646 gene product from transcript CG6646-RA; DJ-1alpha [Source:FlyBase gene name;Acc:FBgn0033885] [Ensembl]; The gene DJ-1α is referred to in FlyBase by the symbol Dmel\DJ-1α (CG6646, FBgn0033885). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: response to oxidative stress. 11 alleles are reported. The phenotypes of these alleles are annotated with: eye; dopaminergic neuron; eye photoreceptor cell; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: DJ-1; ThiJ/PfpI. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. [FlyBase] Observation: RNA interference of DJ-1alpha shortens maximum lifespan by 13% and results in increased sensitivity to oxidative stress and motor impairments [17651920]. Assays: Organismal Lifespan Maximum: -13 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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