CDC7

Symbol: CDC7
Name: Cell Division Cycle 7
Alias: LSD6;SAS1
Entrez gene ID: 851545
Ensembl gene ID: YDL017W
Species: Yeast (Taxid: 4932)

Functional description:
Cdc7p; DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression [Source:SGD;Acc:S000002175] [Ensembl]; DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p [SGD]

Observation:

Transient inactivation of CDC7 results in a shortened replicative lifespan [2698814]. CDC7 participates in silencing and RAS2 modulates its activity [1990268].



Interventions:
  • Transient CDC7 inactivation

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 1990268: A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CG5790 (7227)
  • AgaP_AGAP002110 (7165)
  • hsk1 (4896)
  • CDC7 (4932)
  • KLLA0C04345g (28985)
  • AGOS_AER216C (33169)
  • GeneID:2676497 (148305)
  • NCU11410 (5141)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit