Denigma

LY294002

Symbol: LY294002
Alias: LY-294002
Species: Fly (Taxid: 7227)

Functional description:
Specific PI3K inhibitor

Observation:

Treatment of Drosophila imago with 5 micromolar LY294002 increases median (by 14%) and maximum (by 16-22%) lifespan (p<0.001) in females and males, respectively [22661237].

Low dose of LY294002 (5 microM) slightly increase the median and maximum lifespan of fruit fly [20017609].



Interventions:
  • LY294002 treatment +14% +16 to +22%

    • Assays: Organismal Lifespan

    Classification:
  • Gero-Suppressant


    • Type:
  • Drug

    References:
  • 22661237: The second international conference "genetics of aging and longevity".
  • 20017609: Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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