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Symbol: aPKC Name: atypical protein kinase C Entrez gene ID: 47594 Ensembl gene ID: FBgn0261854 Species: Fly (Taxid: 7227) Functional description: atypical protein kinase C; atypical protein kinase C [Source:FlyBase gene name;Acc:FBgn0261854] [Ensembl]; The gene atypical protein kinase C is referred to in FlyBase by the symbol Dmel\aPKC (CG42783, FBgn0261854). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein serine/threonine kinase activity. There is experimental evidence for 18 unique biological process terms, many of which group under: cell fate commitment; cellular component organization or biogenesis; sensory organ development; cellular process; germarium-derived oocyte differentiation; immune response; learning or memory; establishment or maintenance of neuroblast polarity; localization; anterior/posterior axis specification; biological regulation; open tracheal system development; establishment or maintenance of polarity of follicular epithelium. 37 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; multicellular structure; external compound sense organ; organ system subdivision; acellular anatomical structure; portion of tissue; anatomical structure; epithelial cell; peripheral nervous system; adult; embryonic/larval integumentary system; imaginal precursor. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Diacylglycerol/phorbol-ester binding; Phox/Bem1p; Protein kinase C, zeta/iota; Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Gene sequence location is 2R:10831963..10850451. [FlyBase] Observation: Insertion of a P-based vectors in the structural part of aPKC increase male and female lifespan [22661237]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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