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Symbol: unc-51 Name: UNCoordinated-51 Entrez gene ID: 180311 Ensembl gene ID: Y60A3A.1 Species: Worm (Taxid: 6239) Functional description: in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. [UniProt] Observation: unc-51(e369) mutation reduces mean but extends maximum lifespan. unc-51(e369) mutation reduces lifespan of eat-2(ad1116) mutants to that of wild-type [18219227]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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