Denigma: Factor

Icariside II

Symbol: Icariside II
Name: Icariside II
Species: Worm (Taxid: 6239)

Observation:

Icariside II and its derivate icarrin extend lifespan. Animals treated with icariin have high levels of icariside II. Icariside II also increases thermo and oxidative stress tolerance, slow locomotion decline in late adulthood and delay the onset of paralysis mediated by polyQ and ABeta(1-42) proteotoxicity. Lifespan extension by Icariside II is dependent on IIS, since daf-16(mu86) and daf-2(e1370) fails to sho exhibit lifespan extension upon icariside treatment. Incariside II treatment upregulates expression of DAF-16 targets in wild-type. HSF-1 has also a role in icariside II-dependent lifespan extension [22216122].

Interventions:

Icariside II treatment

Assays: Organismal Lifespan

Classification:

Gero-Suppressant

Type:

Drug

References:

22216122: Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.

Aging Relevance Analysis/Source:

GenAge