Denigma

VPS36

Symbol: VPS36
Name: Vacuolar Protein Sortin 36
Alias: GRD12;VAC3;VPL11
Entrez gene ID: 851135
Ensembl gene ID: YLR417W
Species: Yeast (Taxid: 4932)

Functional description:
Vps36p; Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome [Source:SGD;Acc:S000004409] [Ensembl]

Observation:

VPS36 deletion mutants have a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825].



Interventions:
  • VPS36 deletion

    • Assays: Chronological Lifespan

    Classification:
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • VPS36 (9606)
  • VPS36 (9598)
  • VPS36 (9615)
  • VPS36 (9913)
  • Vps36 (10090)
  • Vps36 (10116)
  • VPS36 (9031)
  • vps36 (7955)
  • Vps36 (7227)
  • AgaP_AGAP004755 (7165)
  • tag-318 (6239)
  • vps36 (4896)
  • VPS36 (4932)
  • KLLA0B02541g (28985)
  • AGOS_AER092W (33169)
  • GeneID:2679344 (148305)
  • NCU06595 (5141)
  • AT5G04920 (3702)
  • Os01g0813500 (4530)



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