GSTZ1

Symbol: GSTZ1
Name: glutathione transferase zeta 1
Alias: GSTZ1-1;MAAI;MAI;MGC2029;LOC2954
Entrez gene ID: 2954
Ensembl gene ID: ENSG00000100577
Species: Human (Taxid: 9606)

Functional description:
Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. [UniProt]

Observation:

rs21116999 located in intron 1 of the GSTZ1 gene was significantly associated with longevity in a population Calabria (Italy).GSTZ1 was found to be associated with longevity [22576335].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2111699 None [22576335]
  • rs2111699 0.0014 [22576335]

  • Classification:
  • Longevity-Associated


  • References:
  • 22576335: MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • GSTZ1 (9606)
  • GSTZ1 (9615)
  • GSTZ1 (9913)
  • Gstz1 (10090)
  • GSTZ1 (9031)
  • zgc:92869 (7955)
  • CG9362 (7227)
  • Y53G8B.1 (6239)
  • gst-43 (6239)
  • gst-42 (6239)
  • Os12g0210300 (4530)
  • Os12g0210200 (4530)



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