MAP3K7

Symbol: MAP3K7
Name: mitogen-activated protein kinase kinase kinase 7
Alias: MEKK7;TAK1;TGF1a;LOC6885
Entrez gene ID: 6885
Ensembl gene ID: ENSG00000135341
Species: Human (Taxid: 9606)

Functional description:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. [UniProt]

Observation:

rs282070 located in intron 1 of MAP3K7 gene was significantly associated with longevity in a Calabria (Italy) population.MAP3K7 was found to be associated with longevity [22576335].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs282070 None [22576335]
  • rs282070 0.0011 [22576335]

  • Classification:
  • Longevity-Associated


  • References:
  • 22576335: MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MAP3K7 (9606)
  • MAP3K7 (9598)
  • MAP3K7 (9913)
  • Map3k7 (10090)
  • Map3k7 (10116)
  • MAP3K7 (9031)
  • map3k7 (7955)
  • Tak1 (7227)
  • mom-4 (6239)
  • Y105C5A.24 (6239)
  • ATMRK1 (3702)

  • Inparanoids
  • ENSP00000358335 (9606)
  • ENSMUSP00000040307 (10090)
  • ENSRNOP00000007654 (10116)
  • ENSMMUP00000008581 (9544)
  • ENSP00000358335 (9606)



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