Rapa

Symbol: Rapa
Name: Rapamycin
Alias: Rap

Functional description:
TOR-kinase inhibitor

Observation:

In budding yeast treatment with rapamcyin increases mean and maximum replicative lifespan by 19 and 16% Rapamycin fails to extend the lifespan of sir2 mutants or NAM treated wild-type cells [20947565]. Rapamcyin treatment increases mean chronological lifespan by by approximately by 80% in BY4742 [22790951]. Rapamycin extends chronological lifespan proportional with increasing concentrations from 100 pg/mL to 1 ng/mL [16418483].

Treatment with rapamcyin in nemaotdes increases mean, median, 75th %ile and maximum lifespan by 19-29, 17-29, 24-32 an 19%, respectively on OP50. On HT115 rapamycyin extends mean, median and 75th %ile of lifespan by 8-36, 4-46 and 12-44%, respectively. Rapamycin robustly increases lifespan in two daf-16 mutants (mgDf47 and mu86) with or without FUdR and with growth on either the standard strain OP50 or the feeding RNAi strain HT115 [22560223].

Treatment of Drosophila imago with rapamycin induces increases of median (by 5-6%) lifespan (p < 0.01) in males and females, respectively and increase of maximum lifespan (by 33%) in females (p < 0.01) [22661237]. Rapamcyin increases mouse lifespan even when administrated late in life [19587680].

Low dose of rapamycin (5 microM) slightly increase the median and maximum lifespan in fruit fly [20017609].

Rapamcyin increases mouse lifespan and healthspan even when administrated late in life (20 months) [19587680].

Rapamycin enhances learning and memory in young mice and improves these faculties in old mice thereby negating the normal decline in these functions with age. Rapamycin boost levels of neurotransmitters associated with neural plasticity. Rapamycin also lowered anxiety and depressive-like behaviour at all ages from 4, 12 and 28 months. "Happy, feel-good" neurotransmitters such as serotonin, dopamine and norepinephrine are all significantly augmented in the midbrains of rapamycin treated mice [http://denigma.de/url/37].

Treatment with rapamycin increased lifespan and suppresses spontanous tumorgenesis in inbred female mice [22107964].



Interventions:
  • Rapamycin treatment
  • Rapamycin treatment +8 to +29% +4 to +46% +19%
  • Rapamycin treatment +5 to +6% +33%
  • Rapamycin treatment +19 to +50% +16%

  • Assays: Replicative Lifespan Chronological Lifespan Organismal Lifespan

    Classification:
  • Gero-Suppressant
  • DR-Mimetic


  • Type:
  • Drug

    References:
  • 19587680: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
  • 22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
  • 22661237: The second international conference "genetics of aging and longevity".
  • 20947565: Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
  • 22790951: New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.
  • 16418483: Extension of chronological life span in yeast by decreased TOR pathway signaling.
  • 22107964: Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.
  • 20017609: Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.


  • Note: Maybe fuse with the mouse one.

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