ragc-1

Symbol: ragc-1
Name: RAs-related GTP binding protein C homolog
Entrez gene ID: 178084
Ensembl gene ID: Y24F12A.2
Species: Worm (Taxid: 6239)

Functional description:
Protein RAGC-1

Observation:

ragc-1 RNAi only during adulthood increases mean, median and maximum lifespan by 13-33, 21 and 33-37% respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Interference with TORC1 by ragc-1 RNAi increases heat resistance in daf-16 and skn-1 mutants, but not not in skn-1;daf-16 double mutant. ragc-1 RNAi increases lifespan in a strain in which RNAi is restricted to the intestine (VP288). RNAi of ragc-1 decreases overall mRNA translation but increases autophagy (measured by LGG-1 puncta) [22560223].



Interventions:
  • ragc-1 RNAi +13 to +33% +21% +33 to +37%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RRAGC (9606)
  • RRAGC (9598)
  • RRAGC (9913)
  • Rragc (10090)
  • Rragc (10116)
  • RRAGC (9031)
  • rragc (7955)
  • RagC (7227)
  • AgaP_AGAP007634 (7165)
  • Y24F12A.2 (6239)



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