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Symbol: hcf-1 Name: Host Cell Factor-1 Alias: human HCF1 related Entrez gene ID: 177560 Ensembl gene ID: C46A5.9 Species: Worm (Taxid: 6239) Functional description: Protein HCF-1; human HCF1 related family member (hcf-1) [Source:RefSeq peptide;Acc:NP_501279] [Ensembl]; hcf-1 encodes the C. elegans ortholog of human host cell factor (HCF-1), a transcriptional regulator that associates with histone modification enzymes and plays a role in cell cycle progression; in C. elegans, hcf-1 plays a role in regulation of cell division and mitotic histone modification; in addition, HCF-1 functions in determination of adult lifespan as a negative regulator of DAF-16, with which it physically interacts; HCF-1 is a ubiquitously expressed protein that localizes to the nucleus. [WormBase] Observation: hcf-1 is conserved protein [12826401], ubiquitously expression in C. elegans under normal culture conditions and predominantly nuclear [7876203]. HCF-1 forms a complex with DAF-16. hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli. The hcf-1(ok559) mutation increases mean and maximum lifespan by 10-37 and 29%, while the strong hcf-1(pk924) mutation extends mean and maximum lifespan by 29-31 and 53-88%, respectively. In the absence of hcf-1 there is a greater enrichment of DAF-16 at its target gene promoters and more robust DAF-16-mediated regulation of selective transcriptional targets. hcf-1 mutation extends lifespan of glp-1(e2141) mutants which lack germline cells, [18828672]. SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification [22568582]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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