Denigma: Factor

VPS8

Symbol: VPS8
Name: Vacuolar Protein Sorting 8
Alias: FUN15;VPT8;VPL8
Entrez gene ID: 851261
Ensembl gene ID: YAL002W
Species: Yeast (Taxid: 4932)

Functional description:
Vps8p; Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif [Source:SGD;Acc:S000000002] [Ensembl]

Observation:

Lack of VPS8 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825].

Interventions:

VPS8 deletion

Assays: Chronological Lifespan

Classification:

DR-Essential

References:

20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

Aging Relevance Analysis/Source:

GenAge