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Symbol: ncbp-2 Name: Nuclear Cap-Binding Protein Entrez gene ID: 184953 Ensembl gene ID: F26A3.2 Species: Worm (Taxid: 6239) Functional description: Protein NCBP-2; Nuclear cap-binding protein subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q93594] [Ensembl]; ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope. [WormBase] Observation: RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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