Denigma: Factor

tbp-1

Symbol: tbp-1
Name: TATA-Binding Protein
Entrez gene ID: 176054
Ensembl gene ID: T20B12.2
Species: Worm (Taxid: 6239)

Functional description:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. [UniProt]

Observation:

RNAi against tbp-1 decreases mean and maximum lifespan by 15-27% and 21%, respectively [18059442].

Interventions:

tbp-1 RNAi -15-27% -21%

Assays: Organismal Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

18059442: A modular network model of aging.

Aging Relevance Analysis/Source:

GenAge