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Symbol: pex1 Name: peroxin 1 Alias: 0848/07;anon-WO0172774.100;anon-WO0172774.101;anon-WO0172774.102;anon-WO0172774.96;anon-WO0172774.98;anon-WO0172774.99;CG6760;DmCAB51031.1;Dmel\\CG6760;l(3)02402;l(3)084807;l(3)70Da;l(3)S084807;l(3)s4868 Entrez gene ID: 45460 Ensembl gene ID: FBgn0013563 Species: Fly (Taxid: 7227) Functional description: peroxin 1; peroxin 1 [Source:FlyBase gene name;Acc:FBgn0013563] [Ensembl]; The gene Peroxin 1 is referred to in FlyBase by the symbol Dmel\Pex1 (CG6760, FBgn0013563). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled. There is experimental evidence that it is involved in the biological process: central nervous system development; glial cell development; peroxisome organization; spermatocyte division; peripheral nervous system development. 7 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; testis. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Aspartate decarboxylase-like fold; Peroxisome biogenesis factor 1, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. [FlyBase] Observation: Mutation of the promoter region of pex1(S4868), results in lower expression levels and increases lifespan in males and females by 16% and 13%, respectively. pex1 mutation increases mean and maximum lifespan and males/females by 27-23/14-19% and 0-15%, respectively [22509016]. Interventions: Assays: Organismal Lifespan Mean: +14 to +27 Maximum: 0 to +15 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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