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Symbol: daf-6 Name: abnormal DAuer Formation Entrez gene ID: 181584 Ensembl gene ID: F31F6.5 Species: Worm (Taxid: 6239) Functional description: Protein DAF-6; abnormal DAuer Formation family member (daf-6) [Source:RefSeq peptide;Acc:NP_510472] [Ensembl]; daf-6 encodes a Patched-related protein; daf-6 is required for amphid channel morphogenesis and thus, also for normal morphology of the outer labial sensilla; specifically, daf-6 is required for restricting the amphid sensory compartment diameter; daf-6 mutants display defects in several neuron-mediated functions including dauer larvae formation, chemotaxis, osmotic avoidance, male mating, negative regulation of lifespan, negative regulation of the neuron ASJ's axonal growth late in development, and dye uptake by amphids and phasmids; a DAF-6::GFP is expressed in the amphid sheath and socket cells and in the excretory canal. The ectopic axonal phenotype of ASJ in daf-6 mutants is temperature-sensitive, being much greater at 25 degrees C than at 15 degrees C. [WormBase] Observation: Loss-of-function mutations in daf-6 extend lifespan by up to 50% [10617200]. daf-6 mutants are dauer defective, chemotaxis defective, osmotic aviodance (osm), male mate poorly, and, dye filling defective [2428682]. Mutants of daf-6 have defective sheath cells causing the amphid and phasmids pores to be closed. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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