his-55

Symbol: his-55
Name: HIStone
Alias: HIStone family member (his-55);WBGENE00001929
Entrez gene ID: 186250
Ensembl gene ID: F54E12.1
Species: Worm (Taxid: 6239)

Functional description:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [UniProt]

Observation:

his-55 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • his-55 RNAi

  • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HIST1H3A (9606)
  • HIST1H3I (9606)
  • HIST1H3G (9606)
  • HIST1H3J (9606)
  • HIST1H3F (9606)
  • HIST1H3C (9606)
  • HIST1H3B (9606)
  • HIST1H3D (9606)
  • HIST1H3E (9606)
  • HIST1H3H (9606)
  • LOC736427 (9598)
  • H3F3B (9598)
  • HIST1H3A (9598)
  • LOC608586 (9615)
  • LOC504599 (9913)
  • LOC619141 (9913)
  • Hist1h3c (10090)
  • Hist1h3f (10090)
  • Hist2h3c2-ps (10090)
  • Hist2h3b (10090)
  • Hist1h3b (10090)
  • Hist1h3e (10090)
  • Hist1h3d (10090)
  • LOC680498 (10116)
  • LOC100329422 (7955)
  • zgc:158629 (7955)
  • LOC564732 (7955)
  • LOC100006146 (7955)
  • LOC100000930 (7955)
  • LOC100006182 (7955)
  • LOC570703 (7955)
  • LOC100004914 (7955)
  • LOC100001294 (7955)
  • LOC563243 (7955)
  • LOC100333965 (7955)
  • LOC560616 (7955)
  • LOC100001555 (7955)
  • LOC100329423 (7955)
  • zgc:173552 (7955)
  • LOC100335000 (7955)
  • LOC100149321 (7955)
  • LOC100334741 (7955)
  • LOC560090 (7955)
  • LOC561114 (7955)
  • LOC560897 (7955)
  • LOC100334933 (7955)
  • LOC100333750 (7955)
  • LOC100332949 (7955)
  • His3:CG33803 (7227)
  • His3:CG31613 (7227)
  • His3:CG33806 (7227)
  • His3:CG33809 (7227)
  • His3:CG33812 (7227)
  • His3:CG33815 (7227)
  • His3:CG33818 (7227)
  • His3:CG33821 (7227)
  • His3:CG33824 (7227)
  • His3:CG33827 (7227)
  • His3:CG33830 (7227)
  • His3:CG33833 (7227)
  • His3:CG33866 (7227)
  • His3:CG33836 (7227)
  • His3:CG33863 (7227)
  • His3:CG33839 (7227)
  • His3:CG33860 (7227)
  • His3:CG33842 (7227)
  • His3:CG33857 (7227)
  • His3:CG33845 (7227)
  • His3:CG33854 (7227)
  • His3:CG33848 (7227)
  • His3:CG33851 (7227)
  • AgaP_AGAP012559 (7165)
  • AgaP_AGAP003910 (7165)
  • AgaP_AGAP012573 (7165)
  • AgaP_AGAP005024 (7165)
  • AgaP_AGAP012572 (7165)
  • AgaP_AGAP005025 (7165)
  • his-25 (6239)
  • his-13 (6239)
  • his-42 (6239)
  • his-59 (6239)
  • his-45 (6239)
  • his-55 (6239)
  • his-63 (6239)
  • his-49 (6239)
  • his-9 (6239)
  • his-32 (6239)
  • his-2 (6239)
  • his-27 (6239)
  • his-17 (6239)
  • his-6 (6239)
  • AT5G65350 (3702)



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