Denigma: Factor

rpt-1

Symbol: rpt-1
Name: proteasome Regulatory Particle, ATPase-like 1
Alias: proteasome Regulatory Particle;ATPase-like family member (rpt-1);WBGENE00004501
Entrez gene ID: 179641
Ensembl gene ID: C52E4.4
Species: Worm (Taxid: 6239)

Functional description:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). [UniProt]

Observation:

rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747].

Interventions:

rpt-1 RNAi -28.4% -50.0%

Assays: Organismal Lifespan
Mean: -28.4
Maximum: -50.0

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge