Denigma

lam-2

Symbol: lam-2
Name: LAMinin related. See also lmb-
Alias: LAMinin related. See also lmb- family member (lam-2);WBGENE00016913
Entrez gene ID: 180980
Ensembl gene ID: C54D1.5
Species: Worm (Taxid: 6239)

Functional description:
LAMinin related. See also lmb-; Protein LAM-2; Laminin-like protein lam-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18823] [Ensembl]; lam-2 encodes a laminin gamma subunit; lam-2 activity is required for embryonic development and for regulation of muscle arm extension; loss of lam-2 function via large-scale RNAi screens results in embryonic, larval, and adult lethality, sterility, body morphology defects, and abnormal locomotion. [WormBase]

Observation:

lam-2 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • lam-2 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • LAMC1 (9606)
  • LAMC1 (9598)
  • LAMC1 (9615)
  • LAMC1 (9913)
  • Lamc1 (10090)
  • Lamc1 (10116)
  • lamc1 (7955)
  • LanB2 (7227)
  • LANB2 (7165)
  • lam-2 (6239)



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