abi-1

Symbol: abi-1
Name: ABl Interactor homolog
Alias: ABl Interactor homolog family member (abi-1);WBGENE00015146
Entrez gene ID: 175789
Ensembl gene ID: B0336.6
Species: Worm (Taxid: 6239)

Functional description:
Protein ABI-1; ABl Interactor homolog family member (abi-1) [Source:RefSeq peptide;Acc:NP_498224] [Ensembl]; abi-1 encodes an Abl interactor orthologous to human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); abi-1 is required for epidermal cell migrations during embryonic enclosure and for proper migration of the excretory cell and mechanosensory and motoneurons; ABI-1 physically interacts with the N-terminus of UNC-53/NAV2, which may provide a link between ABI-1 and the ARP2/3 complex; ABI-1 also physically interacts with ABL-1, and is required for apoptotic cell engulfment and normal distal tip cell migration; ABI-1 is expressed in a number of head and nerve ring neurons including the amphid interneurons AIYL/R and the RMEL/R motoneurons, several types of ventral cord motoneurons and the coelomocytes; in neurons, ABI-1 localizes to the cell bodies, dendrites and commissural axons. [WormBase]

Observation:

abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • abi-1 RNAi

  • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ABI2 (9606)
  • ABI2 (9598)
  • ABI2 (9615)
  • ABI2 (9913)
  • Abi2 (10090)
  • Abi2 (10116)
  • ABI2 (9031)
  • zgc:153663 (7955)
  • abi-1 (6239)



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