F43G9.5

Symbol: F43G9.5
Name: yeast Enhancer of DeCapping homolog
Alias: hypothetical protein;WBGENE00009668
Entrez gene ID: 172657
Ensembl gene ID: F43G9.5
Species: Worm (Taxid: 6239)

Functional description:
Protein CFIM-1; Protein CFIM-1 [Source:UniProtKB/TrEMBL;Acc:Q93716] [Ensembl]; F43G9.5 encodes a NUDIX hydrolase that that inhibits DHC-1 in vivo, and is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; F43G9.5(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that F43G9.5 negatively regulates dynein; while loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage, F43G9.5 is required for embryonic development, fertility, and general health in mass RNAi assays. [WormBase]

Observation:

F43G9.5 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • F43G9.5 RNAi

  • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • NUDT21 (9606)
  • NUDT21 (9598)
  • NUDT21 (9615)
  • NUDT21 (9913)
  • Nudt21 (10090)
  • Nudt21 (10116)
  • cpsf5 (7955)
  • CG3689 (7227)
  • AgaP_AGAP007242 (7165)
  • F43G9.5 (6239)
  • GeneID:2679618 (148305)
  • NCU09014 (5141)
  • AT4G25550 (3702)
  • Os04g0683100 (4530)



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