Denigma

F10C2.4

Symbol: F10C2.4
Name: Kinase UPstream gene (in operon)
Alias: hypothetical protein;WBGENE00008645
Entrez gene ID: 179652
Ensembl gene ID: F10C2.4
Species: Worm (Taxid: 6239)

Functional description:
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). [UniProt]

Observation:

F10C2.4 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • F10C2.4 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • POLD1 (9606)
  • POLD1 (9615)
  • POLD1 (9913)
  • Pold1 (10090)
  • Pold1 (10116)
  • pold1 (7955)
  • DNApol-delta (7227)
  • F10C2.4 (6239)
  • cdc6 (4896)
  • POL3 (4932)
  • KLLA0E01607g (28985)
  • AGOS_AFL189W (33169)
  • GeneID:2678275 (148305)
  • NCU01192 (5141)
  • EMB2780 (3702)
  • Os11g0186400 (4530)
  • PF10_0165 (5833)



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