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Symbol: sur-2 Name: SUppressor of activated let-60 Ras Alias: SUppressor of activated let-60 Ras family member (sur-2);WBGENE00006349 Entrez gene ID: 173345 Ensembl gene ID: F39B2.4 Species: Worm (Taxid: 6239) Functional description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells. [UniProt] Observation: sur-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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