C14A4.11

Symbol: C14A4.11
Name: Cell-death-Related Nuclease
Alias: hypothetical protein;WBGENE00007561
Entrez gene ID: 174638
Ensembl gene ID: C14A4.11
Species: Worm (Taxid: 6239)

Functional description:
Protein C14A4.11; Protein C14A4.11 [Source:UniProtKB/TrEMBL;Acc:Q17958] [Ensembl]; C14A4.11 encodes a protein with similarity to vertebrate programmed cell death protein 10, also known as TFAR15 or CCM3, which is associated with cerebral cavernous malformations type 3 (OMIM:603285); in C. elegans, deletion mutations in C14A4.11 are associated with sterility and lethality and large-scale RNAi experiments targeting C14A4.11 result in embryonic lethality, body morphology defects, and maternal sterility; large-scale expression studies show that C14A4.11 is widely expressed from mid-embryogenesis onward, with consistent expression seen in the intestine and the vulva. [WormBase]

Observation:

C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • C14A4.11 RNAi

  • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PDCD10 (9606)
  • PDCD10 (9598)
  • PDCD10 (9615)
  • PDCD10 (9913)
  • Pdcd10 (10090)
  • Pdcd10 (10116)
  • PDCD10 (9031)
  • pdcd10a (7955)
  • CG5073 (7227)
  • AgaP_AGAP008287 (7165)
  • C14A4.11 (6239)



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