Symbol: C14A4.11 Name: Cell-death-Related Nuclease Alias: hypothetical protein;WBGENE00007561 Entrez gene ID: 174638 Ensembl gene ID: C14A4.11 Species: Worm (Taxid: 6239) Functional description: Protein C14A4.11; Protein C14A4.11 [Source:UniProtKB/TrEMBL;Acc:Q17958] [Ensembl]; C14A4.11 encodes a protein with similarity to vertebrate programmed cell death protein 10, also known as TFAR15 or CCM3, which is associated with cerebral cavernous malformations type 3 (OMIM:603285); in C. elegans, deletion mutations in C14A4.11 are associated with sterility and lethality and large-scale RNAi experiments targeting C14A4.11 result in embryonic lethality, body morphology defects, and maternal sterility; large-scale expression studies show that C14A4.11 is widely expressed from mid-embryogenesis onward, with consistent expression seen in the intestine and the vulva. [WormBase] Observation: C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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