Denigma

vig-1

Symbol: vig-1
Name: VIG (Drosophila Vasa Intronic Gene) ortholog
Alias: VIG (Drosophila Vasa Intronic Gene) ortholog family member (vig-1);WBGENE00006924
Entrez gene ID: 173512
Ensembl gene ID: F56D12.5
Species: Worm (Taxid: 6239)

Functional description:
Protein VIG-1; VIG (Drosophila Vasa Intronic Gene) ortholog family member (vig-1) [Source:RefSeq peptide;Acc:NP_740971] [Ensembl]; vig-1 encodes a predicted RNA-binding protein orthologous to Drosophila VIG (Vasa Intronic Gene); vig-1 activity is required for proper function of the let-7 miRNA in vivo and thus, for regulating the transition from late larval to adult cell fates; VIG-1 is a component of the 250 kDa RNA-induced silencing complex (RISC) complex and co-immunoprecipates with both TSN-1, the C. elegans Tudor-SN ortholog, and the let-7 miRNA. [WormBase]

Observation:

vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • vig-1 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SERBP1 (9606)
  • SERBP1 (9598)
  • SERBP1 (9615)
  • Serbp1 (10090)
  • Serbp1 (10116)
  • SERBP1 (9031)
  • serbp1 (7955)
  • LOC100332749 (7955)
  • vig (7227)
  • vig2 (7227)
  • CG41503 (7227)
  • vig-1 (6239)



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