Denigma

orc-2

Symbol: orc-2
Name: ORC family
Alias: ORC family member (orc-2);WBGENE00003882
Entrez gene ID: 174676
Ensembl gene ID: F59E10.1
Species: Worm (Taxid: 6239)

Functional description:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). [UniProt]

Observation:

orc-2 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • orc-2 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ORC2 (9606)
  • ORC2 (9598)
  • ORC2 (9615)
  • ORC2 (9913)
  • Orc2 (10090)
  • Orc2l (10116)
  • ORC2L (9031)
  • zgc:153041 (7955)
  • Orc2 (7227)
  • AgaP_AGAP000474 (7165)
  • orc-2 (6239)
  • orc2 (4896)
  • GeneID:2680558 (148305)
  • NCU01370 (5141)
  • ORC2 (3702)
  • Os03g0184700 (4530)



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