Denigma: Factor

hmg-4

Symbol: hmg-4
Name: HMG 4
Alias: HMG family member (hmg-4);WBGENE00001974
Entrez gene ID: 176052
Ensembl gene ID: T20B12.8
Species: Worm (Taxid: 6239)

Functional description:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). [UniProt]

Observation:

hmg-4 RNAi in the adulthood extends mean lifespan by 7%, without an effect on maximum lifespan [23144747].

Interventions:

hmg-4 RNAi +6.5% 0%

Assays: Organismal Lifespan
Mean: +7
Maximum: 0

Classification:

Gerontogene

Positive Gerontogene

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge